解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to induce apoptosis in a variety of cancer cells, including colon, prostate, breast and leukemia. Among them, aspirin, a classical NSAID, shows promise in cancer therapy in certain types of cancers. We hypothesized that aspirin...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1304
更新日期:2012-04-01 00:00:00
abstract::Patients with long-standing ulcerative colitis (UC) have higher risk of developing colorectal cancer. Albeit the causes remain to be understood, epigenetic alterations have been suggested to play a role in the long-term cancer risk of these patients. In this work, we developed a novel microarray platform based on meth...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1283
更新日期:2012-04-01 00:00:00
abstract::Genetically engineered stem cells (GESTECs) producing suicide enzymes and immunotherapeutic cytokines have therapeutic effects on tumors, and may possibly reduce the side effects of toxic drugs used for treatments. Suicide enzymes can convert non-toxic pro-drugs to toxic metabolites that can reduce tumor growth. Cytos...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1288
更新日期:2012-04-01 00:00:00
abstract::Osteosarcoma is the most common primary malignancy of the bone. There have been some advances in surgical and chemotherapeutic strategies, but it is still a tumor with a high mortality rate in children and young adults. Mitogen-activated protein kinase/extracellular signal regulated...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1303
更新日期:2012-04-01 00:00:00
abstract::Advanced castration-resistant prostate cancer has high mortality rates and limited treatment options. Novel therapies are needed to better contend with this disease. Polysaccharide-K® (PSK), an extract of the mushroom Trametes versicolor, has immunomodulatory and tumor suppressive a...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1292
更新日期:2012-04-01 00:00:00
abstract::Smac/DIABLO promotes apoptosis by antagonizing inhibitor of apoptosis proteins. The expression of Smac/DIABLO in tissues has been reported in various cancers; however, little is known about circulating levels of Smac/DIABLO. The present study was designed to first determine if Smac/...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1324
更新日期:2012-04-01 00:00:00
abstract::The efficacy of resveratrol as a preventive agent against the growth of t(4;11) acute lymphoblastic leukemia (ALL) was evaluated in NOD.CB17-Prkdcscid/J mice engrafted with the human t(4;11) ALL SEM cell line. SEM cells were injected into the tail vein and engraftment was monitored ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1316
更新日期:2012-04-01 00:00:00
abstract::The microtubule associated tumor suppressor gene 1 (MTUS1) is a recently published tumor suppressor gene, which has also been shown to act as an early component in the growth inhibitory signaling cascade of the angiotensin II type 2 receptor (AT2R). In this study we report the generation of MTUS1 knock-out (KO) mice, ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1311
更新日期:2012-04-01 00:00:00
abstract::We investigated the expression and promoter methylation of dbpA in human hepatocellular carcinoma (HCC) and examined their correlation with clinicopathological features. In 96 paired samples of HCC and adjacent non-tumorous liver, and 10 normal liver specimens, dbpA mRNA was quantif...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1282
更新日期:2012-03-01 00:00:00
abstract::The most common therapeutic approach for many cancers is chemotherapy. However, many patients relapse after treatment due to the development of chemoresistance. Recently, targeted therapies represent novel approaches to destroy cancer cells. The PI3K/PTEN/AKT pathway is a key signal...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:10.3892/ijo.2011.1312
更新日期:2012-03-01 00:00:00
abstract::Nitric oxide (NO) shows tumoricidal activity. We had previously reported that NO downregulates the phosphatidylinositol-3-kinase/Akt pathway, but upregulates the MEK/ERK pathway downstream of growth factor signaling. We hypothesized that NO donor and MEK inhibitor in combination syn...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1243
更新日期:2012-03-01 00:00:00
abstract::Initiation of protein translation by the 5' mRNA cap is a tightly regulated step in cell growth and proliferation. Aberrant activation of cap-dependent translation is a hallmark of many cancers including non-small cell lung cancer. The canonical signaling mechanisms leading to trans...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1252
更新日期:2012-02-01 00:00:00
abstract::EMMPRIN (extracellular matrix metalloproteinase inducer)/CD147, a membrane-bound glycoprotein with two extracellular loop domains (termed loops I and II), progresses tumor invasion and metastasis by increasing the production of matrix metalloproteinase (MMP) in peritumoral stoma cel...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1224
更新日期:2012-01-01 00:00:00
abstract::Cervical cancer constitutes the second most common cancer in women. It is evident from earlier studies that epidermal growth factor (EGF) is a mitogen, in that it mimics the function of estrogen by mediating cross-talk with other oncoproteins. Although epidermal growth factor recept...
journal_title:International journal of oncology
pub_type: 杂志文章,收录出版
doi:10.3892/ijo.2011.1211
更新日期:2012-01-01 00:00:00
abstract::The expression of microRNA-375 (miR-375) is significantly reduced in cancer tissues of maxillary sinus squamous cell carcinoma (MSSCC). The aim of this study was to investigate the functional significance of miR-375 and a possible regulatory role in the MSSCC networks. Restoration o...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1196
更新日期:2012-01-01 00:00:00
abstract::Although mesenchymal stem cells (MSCs) are considered to be the cells of origin for most sarcomas, the role of MSCs as a source of tumor stroma is not fully understood in this tumor type. The current study investigated whether MSCs affect the tumor growth and metastatic ability in r...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1220
更新日期:2012-01-01 00:00:00
abstract::Newcastle disease virus (NDV) is an avian paramyxovirus with oncolytic properties which shows promising effects in the treatment of cancer. Anti-cancer effects are due to the virus ability: i) to replicate in and kill tumor cells, leading finally to their selective elimination; and ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1222
更新日期:2012-01-01 00:00:00
abstract::Fucoidan, a sulfated polysaccharide, has significant cytotoxic activity against tumor cells; however, the mechanism(s) of this action remains poorly understood. The present study was designed to determine the in vitro and in vivo effects of fucoidan and their molecular mechanisms. F...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1168
更新日期:2012-01-01 00:00:00
abstract::Most tissue microarray studies have used a single 0.6-mm tissue core per donor tissue. It has been suggested that multiple cores per donor can increase the representativity of tissue microarray studies. To estimate the potential benefit of multiple cores, we analyzed Ki67 and p53 in...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1216
更新日期:2012-01-01 00:00:00
abstract::A relevant animal model is critical for investigating the pathogenic mechanisms underlying hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC). Mice are not naturally infected by HBV, presumably due to the lack of HBV receptors on mouse hepatocytes. To bypass this entry step of HBV infection, we report gene...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1145
更新日期:2011-12-01 00:00:00
abstract::Peptide hormone relaxin produced in normal and cancer prostate cells can stimulate prostate cancer progression. Suppression of relaxin or relaxin receptor RXFP1 expression inhibited prostate cancer both in vitro and in vivo. RXFP1 is a G protein-coupled receptor with the extracellular low density lipoprotein A (LDL-A)...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1159
更新日期:2011-12-01 00:00:00
abstract::Experimental studies have established that the sulfated glycosaminoglycans heparan sulfate and chondroitin sulfate act as co-receptors of cytokines and growth factors that drive the malignant cell phenotype and the remodelling of the surrounding tumor stroma. However, the clinical relevance of these studies remains il...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1164
更新日期:2011-12-01 00:00:00
abstract::Paclitaxel (taxol) has been used for the treatment of various human tumors and is an exceedingly efficient chemotherapy agent against esophageal cancer. However, the precise molecular mechanisms of paclitaxel effects on human esophageal adenocarcinoma cells are not well understood. MTT assay and cell cycle analysis we...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1135
更新日期:2011-12-01 00:00:00
abstract::In the present study, a series of seven synthetic croma-kalim analogues were prepared and evaluated for cytotoxic effect on human cervical carcinoma HeLa cells using WST-8 assay. A preliminary screening of these cromakalim analogues showed that 1-[(3S,4R)-4-(2-ethoxy-4-methyl-1H-pyrrol-1-yl)-3-hydroxy- 2,2-dimethylchr...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1153
更新日期:2011-12-01 00:00:00
abstract::Human papillomavirus 16 (HPV-16) is strongly associated with the development of 50% of cervical cancers. The E6 and E7 proteins encoded by high-risk HPV types are associated with the immune evasion of cervical cancer cells, but the mechanism is poorly understood. The purpose of this study was to investigate whether ce...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1108
更新日期:2011-11-01 00:00:00
abstract::The presence of tumor cells in the bone marrow (BM) could be relevant to identifying high risk of disease progression and death in gastrointestinal cancer. However, the molecular profile associated with disseminated tumor cells (DTCs) homing to the BM has yet to be defined. MicroRNAs (miRNA) play key roles in cellular...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1112
更新日期:2011-11-01 00:00:00
abstract::The prognosis for patients with head and neck tumors (HNSCC) is poor, due among other things to the high-risk factor for locoregional recurrence and/or second primary tumors. Extensive studies on chemoprevention of oral pre-cancers to stop carcinogenesis and to prevent recurrence and/or second primary tumors have fail...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1139
更新日期:2011-11-01 00:00:00
abstract::Epidemiologic studies on the protective role of omega-3 fatty acids (n:3) on breast cancer prevention remain inconclusive but studies in preclinical models provide more positive outcome. However, the mechanisms accounting for the protective effect of n:3 are not defined. In the present study, conducted in the N-methyl...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1133
更新日期:2011-11-01 00:00:00
abstract::Narrow band imaging (NBI) has been used in the gastrointestinal endoscopy field as a novel endoscopic imaging technique and has contributed to improved qualitative diagnosis and detection of lesions. However, there are only a few studies of use of NBI in the gynecology field. We applied NBI in flexible hysteroscopy at...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1131
更新日期:2011-11-01 00:00:00
abstract::Although a number of recent studies have reported the involvement of leptin in colorectal carcinogenesis, findings are contradictory and difficult to interpret. Our group has previously reported that leptin signaling might have an important role in the development of colorectal adenomas. In this study, we investigated...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1105
更新日期:2011-10-01 00:00:00
abstract::The Leydig cell tumor, derived from interstitial cells, is a rare neoplasm. In most cases, Leydig cell tumors are benign, however, if the tumor is malignant, no effective treatments are currently available. In this study, we aimed to evaluate the effects of icariin on the growth of the mouse Leydig tumor cell line MLT...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1086
更新日期:2011-10-01 00:00:00
abstract::Endosialin emerged recently as a potential therapeutic target for sarcoma. Since some sarcoma subtypes, such as Ewing's sarcoma, show characteristics of neuroendocrine differentiation, we wondered whether cancers with neuro-endocrine properties and/or neuroectodermal origin, such as neuroblastoma, small cell lung canc...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1091
更新日期:2011-10-01 00:00:00
abstract::Linear accelerator-based radiotherapy has little effect on tumors such as malignant melanoma, various types of sarcoma, and most locally-advanced neoplasms that have grown to several centimeters or more. These tumors contain many hypoxic cancer cells or large amounts of anti-oxidative enzymes, and are therefore resist...
journal_title:International journal of oncology
pub_type: 临床试验,杂志文章
doi:10.3892/ijo.2011.1069
更新日期:2011-09-01 00:00:00
abstract::We performed this study in order to evaluate the impact of the chemokine CXCL12 and its single-nucleotide polymorphism (SNP) rs1801157 on clinicopathological parameters and survival in patients undergoing surgery for esophagogastric cancer. The expression pattern of CXCL12 and its polymorphisms were analyzed by RT-PCR...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1044
更新日期:2011-08-01 00:00:00
abstract::Dickkopf-1 (Dkk1), a negative regulator of the Wnt signaling pathway, is implicated in tumorigenesis in several types of cancer. The purpose of this study was to determine the involvement of Dkk1 in oral squamous cell carcinoma (OSCC). We found that Dkk1 is frequently upregulated in OSCC-derived cell lines and primary...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1046
更新日期:2011-08-01 00:00:00
abstract::CDC28 protein kinase regulatory subunit 2 (CKS2) is a cyclin-dependent kinase subunit (CKS) family member that participates in cell cycle regulation. Few studies have investigated its involvement in gastric cancer. In this study, we focused on the clinical and biological significance of CKS2 over-expression in gastric...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1056
更新日期:2011-08-01 00:00:00
abstract::We have previously shown that the genotoxin-induced apoptosis in mouse embryo fibroblasts was enhanced by the extracellular matrix protein fibronectin (FN). In the present study, we tested the hypothesis that FN regulates the DNA damage response (DDR) signaling pathways in HCT116 (p53-wt) and HT29 (p53-mut) human colo...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1034
更新日期:2011-08-01 00:00:00
abstract::The aim of this study was to determine the prevalence of human papillomavirus (HPV) in patients with laryngeal benign lesions (LBLs) and laryngeal squamous cell carcinomas (LSCCs) using a sensitive E6/E7 type-specific PCR. Paraffin-embedded samples from LBL (n=39) and LSCC patients (n=67) were evaluated for the presen...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1031
更新日期:2011-07-01 00:00:00
abstract::Golgi phosphoprotein 2 (GP73) is a type II Golgi protein, which was found on examination of the fucosylated proteome as a potential tumor marker for hepatocellular carcinoma (HCC). The serum levels of both total and fucosylated GP73 were increased in the sera of patients with HCC. Fucosylation is one of the most impor...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1005
更新日期:2011-07-01 00:00:00
abstract::An ETS family member, ETS Related Gene (ERG) is involved in the Ewing family of tumors as well as leukemias. Rearrangement of the ERG gene with the TMPRSS2 gene has been identified in the majority of prostate cancer patients. Additionally, overexpression of ERG is associated with unfavorable prognosis in prostate canc...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2011.1014
更新日期:2011-07-01 00:00:00